Flibanserin: Enhances Female Sexual Desire and Satisfaction
| Produktdosering: 100mg | |||
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Synonymer | |||
Flibanserin is a prescription medication specifically developed to address hypoactive sexual desire disorder (HSDD) in premenopausal women. It represents a significant advancement in the treatment of female sexual dysfunction, offering a pharmacological approach to a complex and often distressing condition. This non-hormonal agent works centrally by modulating neurotransmitters in the brain to help restore sexual desire. It is the first FDA-approved medication of its kind, marking a pivotal moment in women’s sexual health.
Features
- Active ingredient: Flibanserin 100 mg
- Pharmacological class: Multifunctional serotonin agonist and antagonist (MSAA)
- Administration: Oral tablet
- Prescription status: Rx-only
- Mechanism of action: Modulates neurotransmitters; acts as a postsynaptic 5-HT1A receptor agonist and a 5-HT2A receptor antagonist
- Standard packaging: 30-tablet bottle
Benefits
- Increases the number of satisfying sexual events (SSEs)
- Enhances overall sexual desire and reduces associated distress
- Improves libido by targeting the neurochemical balance in the brain
- Offers a non-hormonal treatment option for premenopausal women
- Can lead to improved intimacy and relationship satisfaction
- Provides a clinically validated approach to managing HSDD
Common use
Flibanserin is indicated for the treatment of acquired, generalized hypoactive sexual desire disorder (HSDD) in premenopausal women. HSDD is characterized by a persistent or recurrent deficiency or absence of sexual fantasies and desire for sexual activity, which causes marked distress or interpersonal difficulty. It is not due to a co-existing medical or psychiatric condition, problems within the relationship, or the effects of a medication or other drug substance. The diagnosis of generalized, acquired HSDD applies to women who previously had no problems with sexual desire.
Dosage and direction
The recommended dosage is 100 mg taken orally once daily at bedtime. Administration at bedtime is recommended to mitigate the risk of certain adverse reactions, such as dizziness, somnolence (sleepiness), and hypotension (low blood pressure), which are more likely to occur shortly after taking the medication. Flibanserin can be taken with or without food, but consistent administration with a light meal or snack may help reduce the incidence of nausea. The tablet should be swallowed whole and not crushed or split. Patients should be advised that it may take up to 8 weeks of daily use to experience a meaningful improvement in symptoms.
Precautions
- Alcohol Interaction: CONTRANDICATED. Concomitant use of alcohol and flibanserin significantly increases the risk of severe hypotension and syncope (fainting). Patients must be advised to completely avoid alcohol.
- Hepatic Impairment: Not recommended in patients with hepatic impairment.
- Hypotension and Syncope: Use with caution in patients with pre-existing low blood pressure or who are on antihypertensive medications. Dizziness and lightheadedness are common, especially upon standing.
- Central Nervous System Depression: Can cause somnolence and sedation. Patients should not drive or engage in other activities requiring full alertness until at least 6 hours after taking the dose and until they know how the medication affects them.
- Pregnancy and Lactation: Not indicated for use in pregnant women. The risks versus benefits should be considered in nursing mothers.
Contraindications
- Concomitant use with alcohol.
- Concomitant use with strong or moderate CYP3A4 inhibitors (e.g., ketoconazole, fluconazole, erythromycin, grapefruit juice).
- Concomitant use with other CNS depressants.
- Patients with hepatic impairment.
- A history of hypersensitivity to flibanserin or any of its excipients.
Possible side effects
The most common adverse reactions (≥2%) are:
- Dizziness
- Somnolence (sleepiness)
- Nausea
- Fatigue
- Insomnia
- Dry mouth Other reported side effects can include:
- Anxiety
- Constipation
- Rash
- Hypotension (low blood pressure), including orthostatic hypotension
- Syncope (fainting)
Drug interaction
Flibanserin is primarily metabolized by the cytochrome P450 enzyme CYP3A4 and, to a lesser extent, CYP2C19. Significant interactions include:
- Strong CYP3A4 Inhibitors (e.g., ketoconazole, itraconazole, ritonavir): CONTRAINDICATED. Concomitant use dramatically increases flibanserin exposure.
- Moderate CYP3A4 Inhibitors (e.g., fluconazole, erythromycin, verapamil, grapefruit juice): CONTRAINDICATED.
- CNS Depressants (e.g., benzodiazepines, narcotics, sleep aids): CONTRAINDICATED or not recommended due to additive sedative effects.
- CYP2C19 Inhibitors (e.g., proton pump inhibitors like omeprazole): May increase flibanserin levels; use with caution.
- Other medications that lower blood pressure: May have an additive hypotensive effect.
Missed dose
If a dose is missed at bedtime, it should be skipped. The patient should NOT take two doses the next day to make up for the missed dose. The regular dosing schedule of one tablet at bedtime should be resumed the following night.
Overdose
In case of suspected overdose, symptomatic and supportive measures should be taken. There is no specific antidote for flibanserin overdose. Due to the drug’s pharmacological profile, the primary risks are expected to be severe hypotension, syncope, and profound CNS depression (somnolence, sedation). Vital signs should be monitored, and the patient should be placed in a recumbent position with legs elevated if hypotensive. Immediate medical attention is required.
Storage
Store at room temperature between 20°C to 25°C (68°F to 77°F). Excursions are permitted between 15°C and 30°C (59°F and 86°F). Keep the bottle tightly closed in its original packaging to protect from light and moisture. Keep out of reach of children and pets.
Disclaimer
This information is for educational purposes only and is not a substitute for professional medical advice, diagnosis, or treatment. Always seek the advice of your physician or other qualified health provider with any questions you may have regarding a medical condition or before starting any new treatment. Never disregard professional medical advice or delay in seeking it because of something you have read here. The efficacy and safety of this product have been established only for its approved use in premenopausal women with HSDD.
Reviews
“After struggling with a complete lack of libido for years, which was causing significant strain in my marriage, my doctor suggested we try flibanserin. The first few weeks were an adjustment with some drowsiness, but by the second month, I noticed a real difference. The constant mental static about sex quieted down, and I found myself actually wanting intimacy again. It’s not a magic pill, but it gave me back a part of myself I thought was gone for good.” – S.K., Age 42
“It’s important for potential users to have realistic expectations. This medication requires strict adherence to the no-alcohol rule and taking it at night is crucial to manage the side effects. For me, the initial dizziness was noticeable. However, persisting with the treatment was worth it. The increase in my spontaneous desire and the decrease in the distress I felt about the issue have been life-changing. It’s a serious medication for a serious condition, and it needs to be treated as such.” – A.L., Age 38
“My experience was mixed. While I did notice a modest improvement in my level of desire, the side effects of fatigue and nausea were too pronounced for me to continue long-term. I appreciate that this option exists, and it clearly works well for some, but it wasn’t the right fit for my body. It underscores the importance of working closely with a doctor to monitor your response.” – J.M., Age 35